反应 #56264

反应方程式

2-Chloroethylisothiocyanate

N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide

DMF

→

3,5-diamino-6-chloro-N-[(2-thiazolinylamino)aminomethylene]-2-pyrazinecarboxamide

反应条件

后处理

1. 1
   其他the solid precipitate is collected
2. 2
   洗涤washed with H2 0
3. 3
   其他dried

实验过程

2-Chloroethylisothiocyanate (670 mg., 0.0055 mole) is added to a warm (40° C.) solution of N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide (1.15 g., 0.005 mole) in DMF (30 ml.) with stirring. After 2 hours, the solid precipitate is collected, washed with H2 0 and dried to give 3,5-diamino-6-chloro-N-[(2-thiazolinylamino)aminomethylene]-2-pyrazinecarboxamide., m.p. 252°-254° C.

来源