反应 #56159

反应方程式

2,6-dichloro-4-phenyl-3-cyano-pyridine

morpholine

→

2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine

收率 86.1%

溶剂

ethanol

反应条件

后处理

1. 1
   温度the resulting mixture was refluxed for about two hours
2. 2
   温度Even while refluxing
3. 3
   温度primarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture
4. 4
   其他a colorless crystalline precipitate formed which
5. 5
   过滤was collected by suction filtration
6. 6
   洗涤very thoroughly washed with water
7. 7
   其他dried

实验过程

A suspension of 24.9 gm (0.1 mol) of 2,6-dichloro-4-phenyl-3-cyano-pyridine in 400 ml of ethanol was slowly admixed with 17.4 gm (0.2 mol) of morpholine, and the resulting mixture was refluxed for about two hours. Even while refluxing, but primarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture, a colorless crystalline precipitate formed which was collected by suction filtration, very thoroughly washed with water and dried. 25.8 gm (86% of theory) of 2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine, m.p. 198°-200° C., were obtained.

来源