反应 #56039

反应方程式

5-cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

hydrazine hydrate

→

5-Cyano-6-methylidene-hydrazino-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

溶剂

methanol

反应条件

后处理

1. 1
   过滤The title compound is filtered off
2. 2
   其他recrystallized from methanol

实验过程

28.7 g of 5-cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) are dissolved in 100 ml of methanol. 5.5 g of hydrazine hydrate are added and the solution is stirred at room temperature over night. The title compound is filtered off and recrystallized from methanol. Yield 20.5 g (68%); m.p. 168°-170° C.

来源