反应 #55799

反应方程式

2-chloromethylpyrimidine

ethylenediamine

N-(2-pyrimidylmethyl)ethylenediamine

methyl isothiocyanate

→

title compound

N-Cyano-N'-methyl-N"-[2-(2-pyrimidylmethylamino)ethyl]-guanidine

反应条件

后处理

1. 1
   其他gives
2. 2
   浓缩after concentrating
3. 3
   其他This thiourea is reacted with lead cyanamide by the procedure of Examples 3(b)

实验过程

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Examples 3(b) to give the title compound.

来源