反应 #55767

反应方程式

Sulphuryl chloride

ethyl 3-oxopentanoate

→

ethyl 2-chloro-3-oxopentanoate

溶剂

chloroform

反应条件

后处理

1. 1
   workup.ADDITIONaddition the mixture
2. 2
   温度heated
3. 3
   温度under reflux for 0.5 hour
4. 4
   温度cooled
5. 5
   洗涤After washing with water, sodium bicarbonate and water
6. 6
   干燥the solution was dried (sodium sulphate)
7. 7
   浓缩concentrated

实验过程

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

来源