反应 #55734

ord-c9d0b6db7a5e4cd096ceeaf647c74a38

反应方程式

CCCCCC.c1ccccc1
benzene hexane
C/C(=C\CO)CCC[C@H](C)CCC[C@H](C)CCCC(C)C
Phytol
[H][H]
hydrogen
→
CC(C)CCCC(C)CCCC(C)CCCC(C)CCO
title compound
收率 82.3%
CC(C)CCCC(C)CCCC(C)CCCC(C)CCO
dihydrophytol
收率 82.3%

反应物

CCCCCC.c1ccccc1
benzene hexane
C/C(=C\CO)CCC[C@H](C)CCC[C@H](C)CCCC(C)C
Phytol
[H][H]
hydrogen

试剂

[Ni]
Ni

溶剂

CCO
ethanol
CCO
ethanol

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    workup.ADDITIONwas added
  2. 2
    其他was absorbed
  3. 3
    过滤After filtering off the catalyst through a filter paper
  4. 4
    其他the ethanol was evaporated

实验过程

Phytol (30.0 g, 0.101 mol) was dissolved in 200 ml of ethanol. A suspension of 1.8 g of Raney-Ni (W-1) in 5 ml of ethanol was added thereto, and hydrogenation was carried out under hydrogen for about 5 hours so that 2405 ml of hydrogen (theoretical volume at 24° C.; 2465 ml) was absorbed. After filtering off the catalyst through a filter paper, the ethanol was evaporated. Yield 29.9 g. Silica gel column chromatography with benzene-hexane (1:1) gave 24.7 g of the title compound (yield 82.3%).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US04221810uspto-grants-1980_09