反应 #554684

反应方程式

3-(1-(Hydroxyimino)ethyl)benzoic acid

HCl

→

sub-title compound

收率 94.0%

3-(1-Aminoethyl)benzoic acid hydrochloride

收率 94.0%

溶剂

ethanol

反应条件

后处理

1. 1
   其他The reaction mixture was purged with nitrogen for 30 minutes
2. 2
   过滤then filtered through a pad of Celite
3. 3
   洗涤washing with methanol
4. 4
   浓缩The filtrate was concentrated in vacuo
5. 5
   其他the residue triturated from Et2O

实验过程

3-(1-(Hydroxyimino)ethyl)benzoic acid (2.28 g, 12.73 mmol) and palladium on carbon (10 wt. %, 1.355 g, 12.73 mmol) in ethanol (170 mL) and 12M aqueous HCl (2.1 mL, 24.2 mmol) were stirred under an atmosphere of H2 at 40 psi for 6 hours. The reaction mixture was purged with nitrogen for 30 minutes then filtered through a pad of Celite washing with methanol. The filtrate was concentrated in vacuo and the residue triturated from Et2O to give the sub-title compound as a white (2.4 g, 94% Yield). 1H NMR (400 MHz, CD3OD) δ 1.66 (d, 3H), 4.55 (q, 1H), 7.58 (t, 1H), 7.70 (d, 1H), 8.07 (d, 1H) and 8.16 (s, 1H); MS (ES+) 166.5.

来源