反应 #554662

反应方程式

6-[(4-fluoro-3-methylphenoxy)methyl]-1-benzyl-2-methylazepane

→

6-[(4-fluoro-3-methylphenoxy)methyl]-2-methylazepane

溶剂

methanol

反应条件

后处理

1. 1
   过滤The suspension was filtered
2. 2
   浓缩the filtrate was concentrated

实验过程

A mixture of 6-[(4-fluoro-3-methylphenoxy)methyl]-1-benzyl-2-methylazepane (2-6, 250 mg, 0.74 mmol, 1.0 equiv) and Pearlman's catalyst (wet 20% Pd(OH)2/C) (78 mg, 0.11 mmol, 0.15 equiv) in methanol (30 mL) was stirred under a hydrogen balloon for 1 hour at 23° C. The suspension was filtered and the filtrate was concentrated to give 6-[(4-fluoro-3-methylphenoxy)methyl]-2-methylazepane (2-7). δ 6.90 (m, 1H), 6.71 (m, 2H), 3.72-1.75 (m, 19H). LRMS m/z (M+H) 252.3 found, 252.2 required.

来源