反应 #554651

反应方程式

LiOH

ethyl 2-acetamidooxazole-4-carboxylate

ethyl 2-aminooxazole-4-carboxylate

Ac2O

→

2-Acetamidooxazole-4-carboxylic acid

溶剂

EtOH

反应条件

后处理

1. 1
   其他Then the solvent is removed in vacuo
2. 2
   workup.ADDITIONSome toluene is added
3. 3
   其他all volatile components are removed in vacuo again
4. 4
   其他The crude product is used without further purification
5. 5
   其他Then the EtOH is removed in vacuo and diluted aq. HCl
6. 6
   workup.ADDITIONis added
7. 7
   其他the resulting precipitate is collected
8. 8
   洗涤washed with cold water
9. 9
   其他dried
10. 10
    其他The resulting product is used without further purification

实验过程

1.0 g (6.41 mmol) ethyl 2-aminooxazole-4-carboxylate and 9.10 mL (96.3 mmol) Ac2O are stirred at r.t. over the weekend. Then the solvent is removed in vacuo. Some toluene is added and all volatile components are removed in vacuo again. This procedure is repeated three times. The crude product is used without further purification. b) 1.31 g (6.60 mmol) of ethyl 2-acetamidooxazole-4-carboxylate are added to 33 mL EtOH. 0.55 g (13.2 mmol) LiOH are added and the resulting mixture is stirred at r.t. over night. Then the EtOH is removed in vacuo and diluted aq. HCl is added and the resulting precipitate is collected, washed with cold water and dried. The resulting product is used without further purification.

来源