反应 #554650

反应方程式

sodium

n-propanol

2-chloro-4-iodo-pyridine

→

4-Iodo-2-propoxy-pyridine

反应条件

后处理

1. 1
   workup.DISSOLUTIONis dissolved completely (ca. 45 min)
2. 2
   workup.STIRRINGThe mixture is stirred
3. 3
   温度at reflux for 3 h
4. 4
   其他The reaction is quenched by the addition of some water
5. 5
   其他The solvent is removed in vacuo and to the residue
6. 6
   workup.ADDITIONare added 20 mL DMF/MeOH
7. 7
   过滤The mixture is filtrated
8. 8
   其他the filtrate is purified by HPLC (MeOH/H2O/NH3)

实验过程

0.58 g (25.06 mmol) sodium are carefully added to 40 mL n-propanol by several portions. The mixture is stirred until the metal is dissolved completely (ca. 45 min). Then 6.00 g (25.1 mmol) 2-chloro-4-iodo-pyridine are slowly added to the mixture. The mixture is stirred at reflux for 3 h. The reaction is quenched by the addition of some water. The solvent is removed in vacuo and to the residue are added 20 mL DMF/MeOH. The mixture is filtrated and the filtrate is purified by HPLC (MeOH/H2O/NH3).

来源