反应 #554649

反应方程式

Ammonia

3-(4-chlorophenyl)-6-chloropyridazine

NaI

HCl

→

3-(4-chlorophenyl)-6-iodopyridazine

溶剂

ACN

water

反应条件

后处理

1. 1
   workup.ADDITIONare added
2. 2
   萃取extracted with EtOAc
3. 3
   干燥dried with Na2SO4
4. 4
   其他the solvent is removed in vacuo
5. 5
   其他The resulting crude product is triturated with TBME

实验过程

20 ml ACN are added to 0.50 g (1.11 mmol) 3-(4-chlorophenyl)-6-chloropyridazine and 3.33 g (22.2 mmol) NaI before 189 μl fuming conc. HCl are added and the mixture is stirred at 80° C. for 4 h. The mixture is alkalised with aq. Ammonia solution (32%) diluted with water and extracted with EtOAc. The org. phases are combined, dried with Na2SO4 and the solvent is removed in vacuo. The resulting crude product is triturated with TBME.

来源