反应 #554648

反应方程式

benzoic acid

2,6-dichloro-5-aminopyrimidine

→

5-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

溶剂

POCl3

反应条件

后处理

1. 1
   过滤The resulting precipitate is filtered
2. 2
   洗涤washed with water
3. 3
   其他dried

实验过程

7.82 g (64.0 mmol) benzoic acid and 20 mL POCl3 are stirred together at 100° C. for 30 min. Within 45 min 7.00 g (42.7 mmol) 2,6-dichloro-5-aminopyrimidine are added by several portions. The reaction mixture is stirred for additional 2 h at the same temperature. After that the mixture is carefully added to an ice cold aq. NaOH solution. The resulting precipitate is filtered, washed with water and dried.

来源