反应 #554646

反应方程式

5-bromo-2-chloropyrimidine

sec-butylamin

ACN

→

5-Bromo-N-sec-butylpyrimidin-2-amine

溶剂

EtOAc

反应条件

后处理

1. 1
   洗涤washed with water (2×)
2. 2
   干燥phase is dried with MgSO4
3. 3
   过滤filtered
4. 4
   其他the solvent is removed in vacuo

实验过程

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4, filtered and the solvent is removed in vacuo.

来源