反应 #554641

反应方程式

acetic anhydride

1-(4-bromophenyl)propane-2-amine

→

N-(1-(4-Bromophenyl)propan-2-yl)acetamide

溶剂

AcOH

反应条件

后处理

1. 1
   其他The solvent is evaporated in vacuo
2. 2
   其他The layers are separated
3. 3
   洗涤the organic layer is washed with water
4. 4
   干燥dried with Na2SO4
5. 5
   过滤filtered
6. 6
   其他the solvent is removed in vacuo
7. 7
   其他The crude product is triturated with DIPE

实验过程

17.0 mL (179.7 mmol) acetic anhydride are added to a mixture of 24.2 g (113 mmol) 1-(4-bromophenyl)propane-2-amine and 20 mL AcOH and the reaction mixture is stirred at r.t. over night. The solvent is evaporated in vacuo, and the residue partitonated between TBME and a saturated aq. NaHCO3 solution. The layers are separated and the organic layer is washed with water, dried with Na2SO4, filtered and the solvent is removed in vacuo. The crude product is triturated with DIPE.

来源