反应 #554640

反应方程式

4-bromophenylacetone

ammonia

hydrogen

→

1-(4-Bromophenyl)propane-2-amine

溶剂

MeOH

反应条件

后处理

1. 1
   其他After complete reaction
2. 2
   过滤the mixture is filtrated
3. 3
   洗涤The residue is washed with MeOH
4. 4
   其他the solvent of the filtrate is removed in vacuo
5. 5
   其他The crude product is used without further purification

实验过程

A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.

来源