反应 #554630

反应方程式

4-fluoro-3-(trifluoromethyl)benzoic acid

TMSCHN2

acetic acid

→

methyl 4-fluoro-3-(trifluoromethyl)benzoate

溶剂

MeOH

CH2Cl2

反应条件

后处理

1. 1
   workup.STIRRINGAfter the reaction was stirred for 10 min
2. 2
   浓缩The mixture was concentrated

实验过程

A solution of 4-fluoro-3-(trifluoromethyl)benzoic acid (260 mg, 1.25 mmol, 1 eq) in MeOH (0.5 mL) and CH2Cl2 (2 mL) was treated with TMSCHN2 (2M in hexanes, 0.85 mL, 1.70 mmol, 1A eq) dropwise with stirring at room temperature. After the reaction was stirred for 10 min, acetic acid was added until the yellow color disappeared. The mixture was concentrated to afford methyl 4-fluoro-3-(trifluoromethyl)benzoate, which was used in the next step without further purification.

来源