反应 #554628

反应方程式

ethyl 3,3-diethoxypropanoate

NaOH

HCl

EtOAc

→

3,3-diethoxypropanoic acid

收率 96.0%

溶剂

water

反应条件

后处理

1. 1
   萃取the aqueous layer was extracted with CH2Cl2
2. 2
   干燥The combined organic layers were dried over MgSO4
3. 3
   过滤filtered
4. 4
   其他evaporated

实验过程

A solution of ethyl 3,3-diethoxypropanoate (4.2 g, 22.0 mmol, 1 eq) and NaOH (1.1 g, 28 mmol, 1.3 eq) in water (8 mL) was heated in a 110° C. oil bath for 1.25 h. The reaction was then cooled to 0° C. and was stirred with concentrated HCl (2.3 mL) and EtOAc (20 mL). The organic layer was saved, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered, and evaporated to afford 3,3-diethoxypropanoic acid (3.41 g, 96% yield) as an orange oil, which was used in the next step without any further purification.

来源