反应 #554624

反应方程式

N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

methylamine

→

2-(4-(Aminomethyl)benzyloxy)4-aminopyrimidine

溶剂

methanol

反应条件

后处理

1. 1
   其他all volatiles are removed in vacuo
2. 2
   其他The product is used without further purification in the next step

实验过程

150 mg (0.46 mmol) of N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1) is dissolved in 2 mL methanol and treated with 5 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231 [M+H]+.

来源