反应 #5546

反应方程式

5-mercaptoimidazo[1,2-a]pyridine

N-[2-(bromo)ethyl]phthalimide

triethylamine

→

desired product

收率 61.1%

5-[2-(phthalimido)ethylthio]imidazo[1,2-a]pyridine

收率 61.1%

溶剂

ethanol

反应条件

后处理

1. 1
   温度heated
2. 2
   温度at reflux for 4 hours
3. 3
   workup.DISTILLATIONAfter the solvent was distilled off
4. 4
   workup.ADDITIONchloroform was added to the residue, which
5. 5
   洗涤was washed with water
6. 6
   干燥dried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off
8. 8
   其他Then, the residue was purified by column chromatography (eluent: ethyl acetate)

实验过程

To a suspension of 5-mercaptoimidazo[1,2-a]pyridine (3.00g, 20 mmoles) and N-[2-(bromo)ethyl]phthalimide (5.59 g, 22 mmoles) in ethanol (200 ml) was added triethylamine (4.2 ml, 30 mmoles) and the mixture was stirred at room temperature for 3 hours and heated at reflux for 4 hours. After the solvent was distilled off, chloroform was added to the residue, which was washed with water, dried over anhydrous magnesium sulfate and the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: ethyl acetate) to obtain 3.95 g of the desired product (61.1%, yellow crystals).

来源