反应 #554593

反应方程式

Tramadol hydrochloride

sodium hydroxide

ethyl acetate

→

tramadol

溶剂

water

反应条件

后处理

1. 1
   workup.DISSOLUTIONdissolved
2. 2
   其他the ethyl acetate fraction was collected
3. 3
   workup.DISTILLATIONFrom this fraction, ethyl acetate was distilled off

实验过程

Tramadol hydrochloride was dissolved in purified water. To this solution, approximately 1.5-fold molar amount of sodium hydroxide was added and dissolved therein. Then, approximately 2-fold volume of ethyl acetate was further added thereto, and the ethyl acetate fraction was collected using a separatory funnel. From this fraction, ethyl acetate was distilled off to obtain tramadol (pKa 9.41) as oil. This tramadol and an equimolar amount of 2-ethylhexanoic acid were added to methanol and uniformly mixed. Then, methanol was distilled off to synthesize 2-ethylhexanoate of tramadol as viscous oil. The obtained viscous oil was directly applied to rock salt plates and measured for its infrared absorption spectrum (FTIR8400S manufactured by Shimadzu Corp.).

来源