反应 #554588

反应方程式

sodium phosphate

squalamine lactate

phosphate

squalamine lactate

→

squalamine phosphate

squalamine lactate

溶剂

dextrose

反应条件

后处理

1. 1
   其他subject with a syringe
2. 2
   其他Over the course of the following 24 hours
3. 3
   workup.WAITThese signs and symptoms persisted for about 1 week

实验过程

A 10 mg/ml solution of squalamine lactate was prepared in 5% dextrose. A squalamine phosphate suspension was prepared by adjusting the 10 mg/ml squalamine lactate solution to 50 mM phosphate by addition of 1M sodium phosphate, pH 7.4. 0.1 ml of each preparation was then separately injected into the subcutaneous space between the thumb and second finger of a healthy human subject with a syringe bearing a 26 gauge needle. Within seconds of injection of the squalamine lactate solution, the subject experienced an intense stinging sensation not unlike an insect sting. This sensation persisted for about 20 minutes. Over the course of the following 24 hours the site became tender, swollen, and visibly red. These signs and symptoms persisted for about 1 week, gradually diminishing in intensity.

来源