反应 #554568

反应方程式

H2O

Benzo[b]thiophene-2-ylboronic acid

9-chlorophenanthridin

sodium carbonate

→

9-Benzothienylphenanthridine

收率 78.0%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度by refluxing under a N2 atmosphere for 5 hours
2. 2
   萃取the mixture was extracted with chloroform
3. 3
   干燥by drying with sodium sulfate
4. 4
   过滤After filtration
5. 5
   其他the filtrate was evaporated to dryness under reduced pressure
6. 6
   其他The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)

实验过程

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

来源