反应 #554566

反应方程式

H2O

Benzo[b]thiophene-2-ylboronic acid

1-chloroisoquinoline

sodium carbonate

→

1-Benzothienylisoquinoline

收率 79.0%

溶剂

toluene

ethanol

反应条件

后处理

1. 1
   温度by refluxing under a N2 atmosphere for 5 hours
2. 2
   萃取the mixture was extracted with chloroform
3. 3
   干燥by drying with sodium sulfate
4. 4
   过滤After filtration
5. 5
   其他the filtrate was evaporated to dryness under reduced pressure
6. 6
   其他The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%)

实验过程

Benzo[b]thiophene-2-ylboronic acid (997 mg, 5.6 mmol) and 1-chloroisoquinoline (946 mg, 5.8 mmol) were dissolved in toluene (20 ml) and ethanol (10 ml), and palladium catalyst (220 mg, 0.19 mmol) and 2M sodium carbonate solution (20 ml) were added thereto, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O, and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%).

来源