反应 #5540

反应方程式

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

phthalic anhydride

→

desired product

收率 84.8%

5-[2-[2-(carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

收率 84.8%

溶剂

chloroform

反应条件

后处理

1. 1
   温度heated
2. 2
   温度at reflux for 5 hours
3. 3
   温度The reaction mixture was cooled
4. 4
   其他The crystals precipitated
5. 5
   过滤were filtered off
6. 6
   洗涤washed with chloroform
7. 7
   其他dried

实验过程

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

来源