反应 #5523

反应方程式

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

溶剂

CH2Cl2

反应条件

后处理

1. 1
   萃取The CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   洗涤The organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   干燥The CH2Cl2 solution was dried (MgSO4)
4. 4
   浓缩concentrated in vacuo

实验过程

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

来源