反应 #550708

反应方程式

farnesyl carboxylic acid

farnesol

triethylamine

2-chloro-1-methylpyridinium iodide

→

titled compound

收率 78.7%

Farnesyl farnesyl carboxylate

收率 78.7%

溶剂

toluene

反应条件

后处理

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   温度the reaction mixture was heated
3. 3
   其他for three hours
4. 4
   温度After cooling
5. 5
   洗涤the mixture was washed with water
6. 6
   干燥dried (Na2SO4)
7. 7
   其他The solvent was removed in vacuo
8. 8
   其他gave a pale yellow oil
9. 9
   其他This material was purified by silica gel chromatography

实验过程

A mixture of farnesyl carboxylic acid (5.0 g), farnesol (4.44 g) and triethylamine (4.85 g) was added dropwise at room temperature to a stirred solution of 2-chloro-1-methylpyridinium iodide (5.61 g) in 40 ml of toluene. After complete addition, the reaction mixture was heated on boiled water bath for three hours. After cooling, the mixture was washed with water and dried (Na2SO4). The solvent was removed in vacuo and gave a pale yellow oil. This material was purified by silica gel chromatography by using n-hexane and gave 7.15 g of the titled compound.

来源