反应 #54985

反应方程式

2-chloro-5-trifluoromethyl-aniline

ethoxymethylenemalononitrile

→

N-(2,2-dicyanovinyl)-2-chloro-5-trifluoromethylaniline

收率 70.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度the mixture is refluxed for 48 hours
2. 2
   温度After cooling
3. 3
   过滤the precipitated product is collected by filtration
4. 4
   洗涤washed with ethanol
5. 5
   其他Recrystallisation from ethanol
6. 6
   其他affords the above product with a melting point of 166°-169° C.

实验过程

19.6 Parts of 2-chloro-5-trifluoromethyl-aniline and 12.2 parts of ethoxymethylenemalononitrile are dissolved in 125 parts of ethanol and the mixture is refluxed for 48 hours. After cooling, the precipitated product is collected by filtration and washed with ethanol. Recrystallisation from ethanol affords the above product with a melting point of 166°-169° C. and in a 70% yield.

来源