反应 #54739

反应方程式

4-isobutylphenylacetonitrile

2,2,2-trifluoroethanol

sulfuric acid

→

4-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester

收率 51.1%

反应条件

后处理

1. 1
   温度were refluxed for 12 hours
2. 2
   萃取The resulting mixture was extracted with ether
3. 3
   其他The ether layer separated
4. 4
   浓缩concentrated
5. 5
   其他to leave an oily residue
6. 6
   workup.DISTILLATIONThe residue was distilled in vacuo

实验过程

A mixture of 1.73 g of 4-isobutylphenylacetonitrile and 10 g of 95% of 2,2,2-trifluoroethanol and 10 g of concentrated sulfuric acid were refluxed for 12 hours. After the reaction was complete, ice-water was added to the mixture. The resulting mixture was extracted with ether. The ether layer separated was dehydrated and concentrated to leave an oily residue. The residue was distilled in vacuo to give 1.4 g of 4-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester as a pale yellow oil, boiling at 77°-79° C./1 mmHg. Analysis-Calculated for C14H17F3O2 : C, 61.30; H, 6.25. Found: C, 61.21; H, 6.23.

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