反应 #54591

反应方程式

water

Chloroform

potassium phthalimide

ethyl-2-bromopentanoate

→

ethyl α-phthalimidopentanoate

溶剂

DMF

dimethylformamide

反应条件

后处理

1. 1
   其他The phases are separated
2. 2
   萃取the aqueous phase is extracted with chloroform
3. 3
   萃取extracted with 0.1 N sodium hydroxide and with water
4. 4
   干燥After drying over sodium sulfate
5. 5
   其他the chloroform is removed

实验过程

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

来源