反应 #54507

反应方程式

ethyl 4-(2-methylphenyl)-3-oxobutanoate

sodium methoxide

1-bromododecane

potassium iodide

→

ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate

溶剂

ethanol

反应条件

后处理

1. 1
   其他The mixture was evaporated to a small volume
2. 2
   workup.ADDITIONdiluted with 100 parts water
3. 3
   萃取extracted with ether
4. 4
   萃取The ether extract
5. 5
   洗涤was washed with saturated sodium bicarbonate, saturated sodium chloride solution
6. 6
   干燥dried over magnesium sulfate
7. 7
   其他Evaporation of the ether

实验过程

Three parts of ethyl 4-(2-methylphenyl)-3-oxobutanoate, 1 part of sodium methoxide, 4.6 parts of 1-bromododecane, 0.5 parts of potassium iodide and 50 parts of absolute ethanol were refluxed together for 4 hours and then stirred 18 hours at room temperature. The mixture was evaporated to a small volume, diluted with 100 parts water and extracted with ether. The ether extract was washed with saturated sodium bicarbonate, saturated sodium chloride solution and dried over magnesium sulfate. Evaporation of the ether gave 6 parts of crude ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate as an oil which was not further purified.

来源