反应 #543611

反应方程式

[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid ethyl ester

LiOH

→

desired product

收率 78.0%

[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid

收率 78.0%

溶剂

MeOH H2O

反应条件

后处理

1. 1
   其他The solvent was then evaporated
2. 2
   workup.DISSOLUTIONresidue dissolved in water
3. 3
   其他precipitated in aq. phase
4. 4
   过滤filtered
5. 5
   洗涤washed few times with water
6. 6
   其他dried

实验过程

A mixture of [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid ethyl ester (1.17 g, 3.07 mmol) and LiOH (645 mg, 15.35 mmol) in MeOH: H2O (3:1, 40 ml) stirred at room temperature for 2 days. The solvent was then evaporated and residue dissolved in water. Upon acidified with 2N HCl to pH 3, product precipitated in aq. phase, filtered and washed few times with water and dried to give the desired product in 78% yield.

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