反应 #543610

反应方程式

water

3,3-diphenyl-1-piperazin-1-yl-propan-1-one

ethyl bromoacetate

K2CO3

→

desired product

收率 60.0%

[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic acid ethyl ester

收率 60.0%

溶剂

DMF

反应条件

后处理

1. 1
   其他Reaction mixture
2. 2
   温度was cooled
3. 3
   萃取The product was extracted with ether
4. 4
   其他dried
5. 5
   其他evaporated
6. 6
   其他The residue was purified by column chromatography

实验过程

To a solution of 3,3-diphenyl-1-piperazin-1-yl-propan-1-one (2.0 g, 6.79 mmol) and ethyl bromoacetate (0.94 ml, 8.49 mmol) in dry DMF (15 ml) was added K2CO3 (2.7 g, 19.53 mmol) and the mixture was heated to 70° C. overnight. Reaction mixture was cooled and water (32 ml) was added. The product was extracted with ether, dried and evaporated. The residue was purified by column chromatography using hexane:ethyl acetate (1:4) to give the desired product in 60% yield.

来源