反应 #543609

反应方程式

4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester

TFA

→

pure product

收率 102.8%

3,3-diphenyl-1-piperazin-1-yl-propan-1-one

收率 102.8%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他resulting mixture
2. 2
   其他Solvent and excess TFA was then evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in CH2Cl2 (150 ml)
4. 4
   洗涤washed with sat. NaHCO3 (2×)
5. 5
   干燥dried over MgSO4
6. 6
   其他Evaporation of solvent

实验过程

To a solution of 4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic acid tert-butyl ester (2.15 g, 5.45 mmol) in dry CH2Cl2 (60 ml) was added TFA (20 ml) and resulting mixture stirred at room temperature for 3 hrs. Solvent and excess TFA was then evaporated and the residue was dissolved in CH2Cl2 (150 ml) and washed with sat. NaHCO3 (2×) and dried over MgSO4. Evaporation of solvent gave 1.65 g of pure product.

来源