反应 #543606

反应方程式

Carbon tetrabromide

N2

2-(2,4-difluoro-phenoxy)-ethanol

triphenyl phosphine

→

4-(2-bromo-ethoxy)-1,3-difluoro benzene

溶剂

EtOAc

CH2Cl2

CH2Cl2

反应条件

后处理

1. 1
   其他the solvent was evaporated under reduced pressure

实验过程

To a cool solution 2-(2,4-difluoro-phenoxy)-ethanol (0.48 g, 2.77 mmol.) in CH2Cl2 (15 ml), triphenyl phosphine (1.3 g, 5 mmol)) was added. Carbon tetrabromide (1.65 g, 5 mmol.) in CH2Cl2 (3 ml) was added to the solution dropwise under N2. The solution was stirred for 30 minutes. EtOAc was added, then the solvent was evaporated under reduced pressure.

来源