反应 #543605

反应方程式

K2CO3

2,4-difluoro phenol

2-Bromoethanol

→

desired product

收率 63.0%

2-(2,4-difluoro-phenoxy)-ethanol

收率 63.0%

溶剂

DMF

EtOAc

反应条件

后处理

1. 1
   温度The mixture was cooled
2. 2
   萃取extracted with water (20 ml), saturated NaCl (4×20 ml)
3. 3
   干燥dried over MgSO4
4. 4
   其他evaporated under reduced pressure
5. 5
   其他The product was purified by column chromatography on silica (Hexane:EtOAc 3:1)

实验过程

K2CO3 (1.07 g, 7.78 mmol) was added to a solution of 2,4-difluoro phenol (0.84 g, 6.48 mmol) in dry DMF (15 ml). 2-Bromoethanol (0.81 g, 6.48 mmol) was added, and the mixture was heated overnight at 120° C. The mixture was cooled, taken up in EtOAc, extracted with water (20 ml), saturated NaCl (4×20 ml), dried over MgSO4, and evaporated under reduced pressure. The product was purified by column chromatography on silica (Hexane:EtOAc 3:1) to give the desired product in 63% yield

来源