反应 #543604

反应方程式

dihydrochloride

(R)-octahydropyrido[1,2-a]pyrazine

diisopropylethylamine

3-chloro-6-(4-trifluoromethylphenyl)-pyridazine

→

title compound

收率 98.1%

(R)-2-[6-(4-Trifluoromethyl-phenyl)-pyridazin-3-yl]-octahydro-pyrido[1,2-a]pyrazine

收率 98.1%

溶剂

dimethylsulfoxide

dichloromethane

反应条件

后处理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   洗涤washed with water (2×15 ml) and brine (15 ml)
3. 3
   干燥The organic layer was dried over magnesium sulphate
4. 4
   其他The solvent was removed in vacuo

实验过程

A mixture of the dihydrochloride salt of (R)-octahydropyrido[1,2-a]pyrazine (649 mg, 3.05 mmol), diisopropylethylamine (1.17 ml, 6.72 mmol), 3-chloro-6-(4-trifluoromethylphenyl)-pyridazine (290 mg, 1.12 mmol) and dimethylsulfoxide (1 ml) was heated in a closed vessel at 160° C. for 40 min. The reaction mixture was cooled to room temperature, diluted with dichloromethane (10 ml) and washed with water (2×15 ml) and brine (15 ml). The organic layer was dried over magnesium sulphate. The solvent was removed in vacuo to give 398 mg of the title compound as the free base.

来源