反应 #543593

反应方程式

Triethylamine

trifluoroacetic acid

[((S)-pyrrolidine-2-carbonyl)amino]acetic acid methyl ester

→

(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

收率 34.4%

溶剂

methanol

反应条件

后处理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux for 16 hours
3. 3
   其他The solvent was removed in vacuo
4. 4
   其他The precipitation
5. 5
   其他was isolated
6. 6
   其他dried in vacuo

实验过程

Triethylamine (75 ml, 540 mmol) was added to a solution of the crude trifluoroacetic acid salt of [((S)-pyrrolidine-2-carbonyl)amino]acetic acid methyl ester (15.4 g), which was isolated in the previous step, in methanol (300 ml). The reaction mixture was heated to reflux for 16 hours. It was cooled to room temperature. The solvent was removed in vacuo. The residue was suspended in 2-propanol (150 ml). The precipitation was isolated and dried in vacuo to give 4.38 g of (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione.

来源