反应 #543587

反应方程式

2-(2H-1,2,3,4-tetraazol-5-yl)phenol

sodium hydroxide

methyl iodide

→

subtitle compound

收率 49.0%

2-(2-Methyl-2H-1,2,3,4-tetraazol-5-yl)phenol

收率 49.0%

溶剂

water

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred for 6 days
2. 2
   其他The organic layer was then separated
3. 3
   洗涤washed with water (2×15 mL)
4. 4
   其他dried
5. 5
   其他Evaporation of solvent and flash chromatography on silica gel (ethyl acetate/heptane, 1:1)

实验过程

To a stirred solution of 2-(2H-1,2,3,4-tetraazol-5-yl)phenol (0.486 g, 3 mmol) and sodium hydroxide (NaOH) (72 mg, 3 mmol) in water (15 mL) a solution of tetrabutylammonium chloride (83 mg, 0.3 mmol) was added. The mixture was stirred for 5 min, then methyl iodide (0.425 g, 0.187 mL, 3 mmol) was added, and the mixture was stirred for 6 days. The organic layer was then separated, washed with water (2×15 mL), and dried. Evaporation of solvent and flash chromatography on silica gel (ethyl acetate/heptane, 1:1) afforded the subtitle compound (0.257 g, 49%).

来源