反应 #543586

反应方程式

hydrochloric acid

2-cyanophenol

sodium azide

ammonium chloride

→

subtitled compound

收率 97.0%

2-(2H-1,2,3,4-Tetrazol-5-yl)phenol

收率 97.0%

溶剂

water

DMF

反应条件

后处理

1. 1
   温度After cooling to room temperature
2. 2
   其他The precipitate formed
3. 3
   过滤was collected by filtration
4. 4
   其他dried

实验过程

A stirred mixture of 2-cyanophenol (2.38 g, 20 mmol), sodium azide (3.9 g, 60 mmol) and ammonium chloride (1.39 g, 26 mmol) in dry DMF (10 mL) was heated at 130° C. for 48 h. After cooling to room temperature, the raction mixture was poured into water (100 mL), and the solution acidified with 6 N hydrochloric acid to pH 1. The precipitate formed was collected by filtration, and dried to give subtitled compound (3.14 g, 97%).

来源