反应 #543585

反应方程式

2-nitro-1,3-benzenediol

acetic anhydride

hydrogen

→

subtitle compound

收率 65.2%

N-(2,6-dihydroxyphenyl)acetamide

收率 65.2%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The catalyst was filtered through celite
2. 2
   其他the solvent evaporated in vacuo
3. 3
   workup.ADDITIONThe oily residue was treated with dichloromethane
4. 4
   其他to afford colourless crystals, which
5. 5
   其他were collected by filteration
6. 6
   其他dried

实验过程

A mixture of 2-nitro-1,3-benzenediol (1.55 g 10 mmol), acetic anhydride (1.59 g, 1.47 mL, 15 mmol) and 10% palladium on charcoal (0.3 g) in methanol (100 mL) was stirred in the atmosphere of hydrogen at atmospheric pressure for 2 h. The catalyst was filtered through celite, the solvent evaporated in vacuo. The oily residue was treated with dichloromethane to afford colourless crystals, which were collected by filteration and dried to give the subtitle compound (1.09 g, 65%).

来源