反应 #543584

反应方程式

2-aminophenol

potassium carbonate

DMF

→

subtitled compound

收率 66.4%

2-(Benzylamino)phenol

收率 66.4%

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   其他Purification by preparative HPLC (Kromasil C18; eluant:acetonitrile+0.1% TFA/water+0.1% TFA)

实验过程

To a stirred mixture of 2-aminophenol (3.0 g, 27.5 mmol), potassium carbonate (6.0 g, 43.4 mmol) and DMF (25 mL) 1-(bromomethyl)benzene (3.75 mL, 31.3 mmol) was added. The mixture was stirred at 60° C. overnight. Purification by preparative HPLC (Kromasil C18; eluant:acetonitrile+0.1% TFA/water+0.1% TFA) gave the subtitled compound (1.82 g, 33%).

来源