反应 #543583

反应方程式

3-chloro-N-(2-hydroxyphenyl)propanamide

aluminium chloride

→

subtitled compound

收率 46.6%

8-Hydroxy-3,4-dihydro-2(1H)-quinolinone

收率 46.6%

反应条件

后处理

1. 1
   温度was heated
2. 2
   其他the reaction mixture was quenched with water (3 ml)
3. 3
   萃取extracted with ethyl acetate (3×5 ml)
4. 4
   其他Evaporation of the solvent and flash chromatography of the residue on silica gel with ethyl acetate/heptane (1:1)

实验过程

A mixture of 3-chloro-N-(2-hydroxyphenyl)propanamide (0.25 g, 1.25 mmol) and aluminium chloride (AlCl3) (0.5 g) was heated with stirring at 130–135° C. for 5 h. After cooling to room temperature, the reaction mixture was quenched with water (3 ml), and extracted with ethyl acetate (3×5 ml). Evaporation of the solvent and flash chromatography of the residue on silica gel with ethyl acetate/heptane (1:1) afforded colourless crystals of the subtitled compound (95 mg, 46.5%).

来源