反应 #543582

反应方程式

2-aminophenol

3-chloropropionyl chloride

→

subtitle compound

收率 77.0%

3-Chloro-N-(2-hydroxyphenyl)propanamide

收率 77.0%

溶剂

acetone

acetone

water

反应条件

后处理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   其他Acetone was removed in vacuo
3. 3
   其他the precipitate formed
4. 4
   过滤was collected by filtration
5. 5
   洗涤washed with water
6. 6
   其他dried

实验过程

To a stirred solution of 2-aminophenol (2.18 g, 20 mmol) in acetone (20 mL) a solution of 3-chloropropionyl chloride (1.28 g, 0.87 mL, 10 mmol) in acetone (20 mL) was added dropwise. After the addition was completed, the reaction mixture was stirred at room temperature for 0.5 h and then diluted with water (50 mL). Acetone was removed in vacuo, the precipitate formed was collected by filtration, washed with water, and dried to give the subtitle compound (1.53 g, 77%).

来源