反应 #543579

反应方程式

methylsalicylate

cyclopropylamine

cyclopropylamine

→

subtitle compound

收率 53.3%

N-Cyclopropyl-2-hydroxybenzamide

收率 53.3%

溶剂

toluene

反应条件

后处理

1. 1
   温度was heated at 80–100° C. for 3 h
2. 2
   其他the residue was purified by silica gel flash chromatography

实验过程

A mixture of methylsalicylate (4.36 g, 28.69 mmol) and cyclopropylamine (1.64 g, 28.69 mmol) was heated at 80–100° C. for 3 h. An additional 0.5 equivalent of cyclopropylamine was added and the reaction mixture was kept at 70° C. for overnight. The reaction mixture was co-evaporated with toluene and the residue was purified by silica gel flash chromatography to give the subtitle compound (2.71 g).

来源