反应 #543573

反应方程式

Methyl iodide

4-(tert-butoxycarbonyl)-2-morpholinecarboxylic acid

potassium carbonate

→

crude product

收率 143.3%

4-(tert-Butyl) 2-methyl 2,4-morpholinedicarboxylate

收率 143.3%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   过滤filtered through Celite
2. 2
   浓缩concentrated
3. 3
   其他The residue was partitioned between dichloromethane and water
4. 4
   干燥The organic phase was dried over magnesium sulfate
5. 5
   浓缩concentrated

实验过程

Methyl iodide (9.38 ml, 150 mmol) was added to a suspension of 4-(tert-butoxycarbonyl)-2-morpholinecarboxylic acid (14.5 g, 62.6 mmol) and dry potassium carbonate (17.3 g, 125 mmol) in dry dimethylformamide (DMF) (360 ml). The mixture was stirred over night, filtered through Celite and concentrated. The residue was partitioned between dichloromethane and water. The organic phase was dried over magnesium sulfate and concentrated to give 22 g of crude product.

来源