反应 #543553

反应方程式

Phenylalanine methyl ester

Cyclohexanoyl chloride

→

N-cyclohexanoylphenylalanine methyl ester

溶剂

pyridine

反应条件

后处理

1. 1
   workup.ADDITIONThe reaction mixture is poured onto hydrochloric acid (1N)
2. 2
   其他crushed ice
3. 3
   萃取The aqueous mixture is extracted twice with toluene
4. 4
   浓缩The combined toluene extracts are concentrated in vacuo

实验过程

Phenylalanine methyl ester (1 g., 0.0046 moles) is dissolved in pyridine 5 mL. Cyclohexanoyl chloride (0.62 mL) is added and the mixture is stirred for 2 hours. The reaction mixture is poured onto hydrochloric acid (1N) and crushed ice. The aqueous mixture is extracted twice with toluene. The combined toluene extracts are concentrated in vacuo to give 1.1 g of crude N-cyclohexanoylphenylalanine methyl ester.

来源