反应 #54291

反应方程式

3-(4-chlorobenzoyl)-benzeneacetic acid chloride

4-(4chlorophenyl)-1-piperazinyl-ethanol

benzene ethyl acetate triethylamine

→

2-[4-(4-chlorophenyl)-1-piperazinyl]-ethyl 3-(4-chlorobenzoyl)-benzeneacetate

反应条件

实验过程

Using the procedure of Example 2, 3-(4-chlorobenzoyl)-benzeneacetic acid chloride was reacted with 4-(4chlorophenyl)-1-piperazinyl-ethanol to obtain 2-[4-(4-chlorophenyl)-1-piperazinyl]-ethyl 3-(4-chlorobenzoyl)-benzeneacetate with an Rf=0.68 (9-1-0.05 benzene-ethyl acetate-triethylamine eluant). Treatment with hydrochloric acid resulted in the formation of the hydrochloride salt melting at 142° C.

来源