反应 #53960

反应方程式

tert-butyl (S)-(2-hydroxy-1-phenyl-ethylamino)-acetate

diphenylacetaldehyde

magnesium sulfate

→

tert-butyl ((4R)-2-benzhydryl-4-phenyl-oxazolidin-3-yl)-acetate

收率 114.1%

溶剂

methylene chloride

ether

反应条件

后处理

1. 1
   洗涤The organic layer was washed with saturated sodium chloride solution
2. 2
   干燥dried over magnesium sulfate
3. 3
   过滤filtered
4. 4
   浓缩concentrated to dryness in vacuo
5. 5
   其他recrystallized from ether/hexanes

实验过程

To a solution of tert-butyl (S)-(2-hydroxy-1-phenyl-ethylamino)-acetate (2.5 g, 10 mmole, obtained from Reference Example 9) in anhydrous methylene chloride (35 ml) were added diphenylacetaldehyde (2.16 g, 11 mmole) and magnesium sulfate (1.2 g, 10 mmole) under nitrogen. The resulting mixture was stirred at room temperature under nitrogen for 15 h, and diluted with ether. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered and concentrated to dryness in vacuo. The oily residue was solidified upon standing, and recrystallized from ether/hexanes to give tert-butyl ((4R)-2-benzhydryl-4-phenyl-oxazolidin-3-yl)-acetate as a white solid (4.9 g, 98%).

来源