反应 #53925

反应方程式

trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester

trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-ammonium trifluoroacetate

→

trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-amine

反应条件

后处理

1. 1
   其他The compound was purified
2. 2
   workup.DISSOLUTIONby dissolving the salt in water
3. 3
   洗涤washing it with Et2O (3×)
4. 4
   萃取extracted with EtOAc (3×)

实验过程

In analogy to example 32.1, trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester was converted to trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-ammonium trifluoroacetate. The compound was purified by dissolving the salt in water, washing it with Et2O (3×). The water phase was adjusted to pH 8 (with aqueous saturated NaHCO3) and extracted with EtOAc (3×) to give trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-amine, MS: 314 (MH+, 1Cl).

来源