反应 #53903

ord-2daaa3b43345406bb478623a4c424ace

反应方程式

CN(C(=O)Oc1ccc(Cl)cc1)[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-{4-[(4-chloro-phenoxycarbonyl)-methyl-amino]-cyclohexyl}-butyl ester
CCNCCO
2-ethylamino-ethanol
→
CCN(CCO)CCCC[C@H]1CC[C@H](N(C)C(=O)Oc2ccc(Cl)cc2)CC1
trans-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-methyl-carbamic acid 4-chloro-phenyl ester

反应物

CN(C(=O)Oc1ccc(Cl)cc1)[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-{4-[(4-chloro-phenoxycarbonyl)-methyl-amino]-cyclohexyl}-butyl ester
CCNCCO
2-ethylamino-ethanol

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

In analogy to examples 31.6, trans-Methanesulfonic acid 4-{4-[(4-chloro-phenoxycarbonyl)-methyl-amino]-cyclohexyl}-butyl ester was treated with 2-ethylamino-ethanol to give trans-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-methyl-carbamic acid 4-chloro-phenyl ester, MS: 411 (MH+, 1Cl).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06858651B2uspto-grants-2005_02